Secţiunea 2 - Conduită - Ghid din 2019 privind anemia feriprivă la gravidă
M.Of. 738 bis
În vigoare Versiune de la: 10 Septembrie 2019
SECŢIUNEA 2:Conduită
I.Profilaxia anemiei
1.Pavord Sue, Myers Bethan, Robinson Susan, Allard Shubha, Strong Jane, Oppenheimer Christina. UK guidelines on the management of iron deficiency in pregnancy. British Journal of Hematology. March 2012; 156(5):588-600
2.Scholl TO. Maternal iron status: relation to fetal growth, length of gestation, and iron endowment of the neonate. Nutr Rev. 2011:69(1):S23-9
3.Milman N. Iron Deficiency and Anaemia in Pregnant Women in Malaysia - Still a Significant and Challenging Health Problem. 2015; J Preg Child Health. 2:168. doi: 10.4172/2376-127X.1000168
4.Krebs NF, Lozoff B, Georgieff MK: Neurodevelopment: the impact of nutrition and inflammation during infancy in low-resource settings. Pediatrics. 2017;139:S50-S58
5.Avila Felipe, Echeverria Guadalupe, Perez Druso, Martinez Carlos, Strobel Pablo, Castillo Oscar, Villaroel Luis, Mezzano Diego, Rozowski Jaime, Urquiaga Ines, Leighton Federico. Serum Ferritin Is Associated with Metabolic Syndrome and Red Meat Consumption. Oxidative Medicine and Cellular Longevity. 2015; Article ID 769739, 8 pages. http://dx.doi.org/10.1155/2015/769739
6.Fleming RE, Ponka P. Mechanisms of disease: Iron overload in human disease. The New England Journal of Medicine. 2012. 366(4): 348-359
7.Wang W, Knovich MA, Coffman LG, Torti FM, Torti SV. Serum ferritin: past, present and future. Biochimica et Biophysica Acta. 2010. 1800(8): 760-769
8.Brudevold R, Hole T, Hammerstrom J. Hyperferritinemia is associated with insulin resistance and fatty liver in patients without iron overload. PLoS ONE. 2008. 3(10), Article ID e3547
9.Andrew M. Prentice, Yery A. Mendoza, Dora Pereira, Carla Cerami, Rita Wegmuller, Anne Constable, Jorg Spieldenner. Dietary strategies for improving iron status: balancing safety and efficacy. Nutr Rev. 2017 Jan; 75(1):49-60
10.Hoppe M, Hulthen L, Hallberg L. The importance of bioavailability of dietary iron in relation to the expected effect from iron fortification. Eur J Clin Nutr. 2008; 62:761-9
11.Julianna Schantz-Dunn, Robert L. Barbieri. Recognize and treat iron deficiency anemia in pregnant women. OBG Management, December 2017, 29(12): 8-16
12.Ryan K, Bain B, Worthington D. Significant haemoglobinopathies; guidelines for screening and diagnosis. British Journal of Haematology. 2010; 149:35-49
13.Michael Alleyne, McDonald K Horne, Jeffery L Miller. Individualized treatment for iron deficiency anemia in adults. Am J Med. 2008 Nov; 121(11): 943-8
14.Congdon L, Westerlund A, Algarin CR, et al. Iron deficiency in infancy is associated with altered neural correlates of recognition memory at 10 years. Journal de Pediatria. 2012; 160:1027-33
15.Siu AL. Screening for Iron Deficiency Anemia and Iron Supplementation in Pregnant Women to Improve Maternal Health and Birth Outcomes: U.S. Preventive Services Task Force Recommendation Statement. Annals of Internal Medicine. 6 October 2015; 163(7):529-37
16.Pena-Rosas JP, Viteri FE. Effects and safety of preventive oral iron or iron+folic acid supplementation for women during pregnancy. Cochrane Database Syst Rev. 2009;4:CD004736. doi: 10.1002/14651858
17.Ziaei S, Norrozi M, Faghihzadeh S, Jafarbegloo E. A randomised placebo-controlled trial to determine the effect of iron supplementation on pregnancy outcome in pregnant women with haemoglobin > = 13.2 g/dl. BJOG. 2007; 114(6):684-8
18.Weinberg ED. Are iron supplements appropriate for iron replete pregnant women? Med Hypotheses. 2009; 73(5):714-5
19.Munoz M, Pena-Rosas JP, Robinson S, Miman N, Holzgneve W, Breymann C, Goffinet F, Nizzard J, Christory F, Samama CM, et al. Patient blood management in obstetrics: Management of anaemia and hematinic deficiencies in pregnancy and in the post-partum period: NATA consensus statement. Transfus. Med. 2018; 28: 22-39
20.Daru J, Zamora J, Fernandez-Felix BM, Vogel J, Oladapo OT, Morisaki N, Tuncalp O, Torloni MR, Mittal S, Jayaratne K, et al. Risk of maternal mortality in women with severe anaemia during pregnancy and postpartum: A multilevel analysis. Lancet Glob Health. 2018; 6:e548-e554
21.Joao Ricardo Friedrisch, Bruno Kras Friedrisch. Prophylactic Iron Supplementation in Pregnancy: A Controversial Issue. Biochem Insights. 2017; 10:1178626417737738
22.Parisi F, Berti C, Mando C, Martinelli A, Mazzali C, Cetin I. Effects of different regimens of iron prophylaxis on maternal iron status and pregnancy outcome: A randomized control trial. J. Matern. Fetal Neonatal Med. 2017; 30:1787-92
23.Camaschella C. Iron-deficiency anemia. N. Engl. J. Med. 2015; 372:1832-43
24.Auerbach M, Adamson JW. How we diagnose and treat iron deficiency anemia. Am J. Hematol. 2016(91):31-8
25.Cancelo-Hidalgo MJ, Castelo-Brando C, Palacios S, Haya-Palazuelos J, Ciria-Recansens M, Manasanch J, Perez-Edo L. Tolerability of different oral iron supllements: A systematic review. Curr. Med. Res.Opin. 2013; 29: 291-303
26.Ojukwu JU, Okebe JU, Yahav D, Paul M Oral iron supplementation for preventing or treating anaemia among children in malaria-endemic areas. Cochrane Database Syst Rev. 2009; 3: CD006589 doi: 10.1002/14651858.CD006589
27.Okebe JU, Yahav D, Shbita R, Paul M. Oral iron supplements for children in malaria-endemic areas. Cochrane Database Syst Rev. 2011; 10: CD006589 doi: 10.1002/14651858.CD006589
28.Pena-Rosas JP, De-Regil LM, Dowswell T, Viteri FE Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev. 2012; 12: CD004736 doi: 10.1002/14651858.CD004736
29.Pena-Rosas JP, De-Regil LM, Dowswell T, Viteri FE Intermittent oral iron supplementation during pregnancy. Cochrane Database Syst Rev. 2012; 7: CD009997 doi: 10.1002/14651858.CD009997
30.Tolkien Z, Stecher L, Mander AP, Pereira DI, Powell JJ. Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: A systematic review and meta-analysis. Plos ONE 2015; 10: e0117383
31.Santiago P. Ferrous versus ferric oral iron formulations for the treatment of iron deficiency: a clinical overview. Scientific World Journal. 2012: 846824
32.Souza AI et al. Adherence and side effects of three ferrous sulfate treatment regimens on anemic pregnant women in clinical trials, Cad. Saude Publica. 2009; 25(6):1225-33
33.Moretti D, Goede JS, Zeder C et al. Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice - daily doses in iron - depleted young women. Blood, 2015; 126:1981-89
34.Stoffel NU, Cercamondi CI, Brittenham G, Zeder C, Geurts-Moespot AJ, Swinkels DW, Moretti D, Zimmermann MB. Iron absorption from oral iron supplememnts given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: Two open-label, randomised controlled trials. Lancet Haematol. 2017; 4:e524-e533
35.Jonathan Baird-Gunning. Correcting iron deficiency. Aust Prescr. 2016 Dec; 39(6):193-9
36.Nagpal J, Choudhury P. Iron formulations in pediatric practice. Indian Pediatrics. 2004; 41(8):807-15
37.Hoffman R, Benz E, Shattil S, et al. Hematology: Basic Principles and Practice. 3rd edition. chapter 16. New York, NY, USA: Churchill Livingstone/Harcourt Brace & Co; 2000
38.Palacios Santiago. Ferrous versus Ferric Oral Iron Formulations for the Treatment of Iron Deficiency: A Clinical Overview. ScientificWorldJournal. 2012; 2012:846824. doi: 10.1100/2012/846824
39.Rajadhyaksha GC, Shahani S, Pawar D. Evaluation of efficacy and tolerability of iron polymaltose complex tablets in iron deficiency anaemia during pregnancy. JAMA India. 2000; 3:53-5
40.Reddy PSN, Adsul BB, Gandewar K, Korde KM, Desai A. Evaluation of efficacy and safety of iron polymaltose complex and folic acid (Mumfer) vs iron formulation (Ferrous Fumarate) in female patients with anaemia. Journal of the Indian Medical Association. 2001; 99(3):154-5
41.Mehta BC. Iron hydroxide polymaltose - cause of persistent iron deficiency anemia at delivery. Indian journal of medical sciences. 2001; 55(11):616-20
42.Geisser P. Safety and efficacy of iron(III)-hydroxide polymaltose complex/a review of over 25 years experience. Arzneimittelforschung. 2007; 57(6A):439-52
43.Fabiano A, Brilli E, Fogli S, Beconcini D, Carpi S, Tarantino G, Zambito Y. Sucrosomial® iron absorption studied by in vitro and ex-vivo models. Eur J Pharm Sci. 2018 Jan 1; 111:425-31
44.Susana Gomez-Ramirez, Elisa Brilli, Germano Tarantino, Manuel Munoz. Sucrosomial Iron: A New Generation Iron for Improving Oral Supplementation. Pharmaceuticals. 2018; 11, 97, doi:10.3390/ph11040097
45.Parag Biniwale, Bhaskar Pal, Tripura Sundari, Gorakh Mandrupkar, Nikhil Datar, Amandeep Singh Khurana, Amit Qamra, Salman Motlekar, Rishi Jain. Liposomal Iron for Iron Deficiency Anemia in Women of Reproductive Age: Review of Current Evidence. September 2018. 8(11):993-1005
46.Akbarzadeh A, Rezaei-Sadabady R, Davaran S, Joo SW, Zarghami N, Hanifehpour Y, et al. Liposome: Classification, Preparation, and Applications. Nanoscale Research Letters. 2013; 8, 102, doi: 10.1186/1556-276X-8-10
47.Pisani A, Riccio E, Sabbatini M, Andreucci M, Del Rio A, Visciano B. Effect of oral liposomal iron versus intravenous iron for treatment of iron deficiency anaemia in CKD patients: a randomized trial. Nephrol Dial Transplant. 2015 Apr; 30(4):645-52
48.German E. Clenin. The treatment of iron deficiency without anaemia (in otherwise healthy persons). Swiss Med Wkly. 2017; 147:w14434. doi: 10.4414/smw.2017.14434. eCollection 2017. Review article
49.Susana A. Gonzalez-Chavez, Sigifredo Arevalo-Gallegos, Quintin Rascon-Cruz, Lactoferrin: structure, function and applications, International Journal of Antimicrobial Agents 33 (2009) 301.e1-301.e8
50.Vito Vetrugno, Safety of milk and milk derivatives in relation to BSE: the lactoferrin example, BioMetals 17: 353-356, 2004.
51.Steijns JM, Van Hooijdonk ACM: Occurrence, structure, biochemical properties and technological characteristics of lactoferrin. Br. J. Nutr. (2000) 84(Suppl. 1): S11-S17.
52.Mamoru Tomita, Hiroyuki Wakabayashi, Kouichirou Shin, Koji Yamauchi, Tomoko Yaeshima, Keiji Iwatsuki, Twenty-five years of research on bovine lactoferrin applications, Biochimie 91 (2009) 52-57
53.Pauline P. Ward & Oria M. Conneely, Lactoferrin: Role in iron homeostasis and host defense against microbial infection, BioMetals 17: 203-208, 2004
54.Peter Ferenc Levay, Margaretha Viljoen, LACTOFERRIN: A GENERAL REVIEW, Haematologica 1995; 80:252-267
55.Robert E. Fleming, and Bruce R. Bacon, Orchestration of Iron Homeostasis, N Engl J Med 352;17, www.nejm.org April 28, 2005
56.Mohamed Rezk, Ragab Dawood, Mohamed Abo-Elnasr, Alaa Al Halaby, and Hala Marawan Lactoferrin versus ferrous sulphate for the treatment of iron deficiency anemia during pregnancy: a randomized clinical trial, J Matern Fetal Neonatal Med, Early Online: 1-4, 2015 Informa UK Ltd. DOI: 10.3109/14767058.2015.1049149
57.R. Paesano, F. Berlutti, M. Pietropaoli, W. Goolsbee, E. Pacifici and P. Valenti, Lactoferrin efficacy versus ferrous sulfate in curing iron disorders in pregnant and non- pregnant women, International Journal of immunopathology and pharmacology, Vol. 23, no. 2, 0-0 (2010)
58.Nappi C, Tommaselli G.A., Morra I., Massaro M., Formisano C., Di Carlo C., Efficacy and tolerability of oral bovine lactoferrin compared to ferrous sulfate in pregnant women with iron deficiency anemia: A prospective controlled randomized study, Acta Obstetricia et Gynecologica 2009, 1-5, iFirst article
59.Pineda, O. & Ashmead, H.D. (2001) Effectiveness of treatment of iron-deficiency anemia in infants and young children with ferrous bis-glycinate chelate. Nutrition, 17, 381-384.
60.Maria Nieves Garcia-Casal, Miguel Layrisse, Liseti Solano, Maria Adela Baron Franklin Arguello, Daisy Llovera, Jose Rami rez, Irene Leets and Eleonora Tropper, Vitamin A and b-Carotene Can Improve Nonheme Iron Absorption from Rice, Wheat and Corn by Humans, American Society for Nutritional Sciences, 12 November 1997
61.Duque X., Martinez H., Vilchis-Gil J., Mendoza E., Flores-Hernandez S., Moran S., Navarro F., Roque-Evangelista V., Serrano A., Mera R.M., Effect of supplementation with ferrous sulfate or iron bis-glycinate chelate on ferritin concentration in Mexican schoolchildren: a randomized controlled trial, Duque et al. Nutrition Journal 2014, 13:71
62.Bovell-Benjamin A.C., Viteri F.E., and Allen L.H., Iron absorption from ferrous bisglycinate and ferric trisglycinate in whole maize is regulated by iron status, Am J Clin Nutr 2000;71:1563-9.
63.Ching-Tzu Lee, Cherng-Jye Jeng, Lian-Shung Yeh, Ming-Shyen Yen, Shih-Ming Chen, Chyi-Long Lee, Willie Lin and Chun-Sen Hsu, A double-blind, randomized, and active-controlled phase III study of Herbiron drink in the treatment of iron-deficiency anemia in premenopausal females in Taiwan, Food & Nutrition Research 2016, 60: 31047 - http://dx.doi.org/10.3402/fnr.v60.31047
64.Allen L.H. (2002) Advantages and limitations of iron amino acid chelates as iron fortificants. Nutr. Rev., 60, S18-S21.
65.Allen L.H., Bovell-Benjamin A.C., Viteri F. (1998) Ferrous bis-and ferric tris-glycinates as iron fortificants for whole maize: bioavailability and regulation by iron status. FASEB J., 12, A821 (Abstract No. 4759).
66.Ashmead S.D. (2001) The chemistry of ferrous bis-glycinate chelate. Arch. Latinoam. Nutr., 51, 7-12.
67.Ashmead H., Ashmead S. (1995) Albion research: Past, present and future. Proceedings of the Albion Laboratories, Inc. International Conference on Human Nutrition. January 21-22 1995, Salt Lake City, Utah, USA, pp. 1-8.
68.Ashmead H.D., Graff D.J., Ashmead H.H. (1985) Intestinal absorption of metal ions and chelates. Springfield: Charles C. Thomas, pp. 113-212.
69.Ashmead H.D., Gualandro S.F.M., Name, J.J. (1997) Increases in haemoglobin and ferritin resulting from consumption of food containing ferrous amino acid (Ferrochel) versus ferrous sulphate. In: Fischer, P.W.F., L’Abbe, M.R., Cockell, K.A. & Gibson, R.S., eds, Proceedings of the 9th International Symposium on Trace Elements in Man and Animals. Ottawa: NRC Research Press, pp. 284-285.
70.Williams G., WHO FOOD ADDITIVES SERIES: 52, FERROUS GLYCINATE (PROCESSED WITH CITRIC ACID), Environmental Pathology and Toxicology, New York Medical College, Valhalla, New York, USA, http://www.inchem.org/documents/jecfa/jecmono/v52je20.htm
II.Principii de tratament în anemia instalată
1.Orlandini C, Torricelli M, Spirito N, Alaimo L, Di Tommaso M, Severi FM, Ragusa A, Petraglia F. Maternal anemia effects during pregnancy on male and female fetuses: are there any differences? J Matern Fetal Neonatal Med. 2017 Jul; 30(14):1704-08
2.Cantwell R, Clutton - Brock T, Cooper G, et al. Saving Mothers' Lives: reviewing maternal deaths to make motherhood safer: 2006-2008. BJOG. 2011; 118(1):1-203. doi: 10.1111/j.1471-0528.2010.02847.x
3.Bamber J. & Kinsella S. MBRRACE-UK - the new home for the confidential enquiries into maternal deaths-reports for the first time. Anaesthesia. 2015 Jan; 70(1):5-9. doi: 10.1111/anae.12938
4.Goonewardene M, Shehata M, Hamad A. Anaemia in pregnancy. Best Practice & Research. Clinical Obstetrics & Gynaecology. 2012; 26:3-24
5.Massimo Franchini, Giovanni Targher, Martina Montagnana, Giuseppe Lippi. Iron and thrombosis. Ann Hematol. 2008 Mar; 87(3):167-73
6.WHO/UNICEF/UNU. Iron deficiency anaemia assessment, prevention, and control: a guide for programme managers. Geneva, World Health Organization, 2001 (http://www.who.int/nutrition/publications/en/ida_assessment_prevention_control.pdf, accesat [30 noiembrie 2018])
7.Auerbach M, James S, Nicoletti M, et al. Results of the first American prospective study of intravenous iron in oral iron-intolerant iron-deficient gravidas. Am J Med. 2017; 130:1402-07
8.Lone FW, Qureshi RN, Emanuel F. Maternal anaemia and its impact on perinatal outcome. Tropical Medicine & International Health. 2004; 9:486-90
9.Beck S, Wojdyla D, Say L, et al. The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity. Bulletin of the World Health Organization. 2010; 88:31-8
10.Batool A Haider, Ibironke Olofin, Molin Wang, Donna Spiegelman, Majid Ezzati, Wafaie W Fawzi. Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis. BMJ. 2013; 346: f3443. doi: https://doi.org/10.1136/bmj.f3443
11.Yiting Zhang, Lei Jin, Jian-meng Liu, Rongwei Ye, Aiguo Ren. Maternal Hemoglobin Concentration during Gestation and Risk of Anemia in Infancy: Secondary Analysis of a Randomized Controlled Trial. J Pediatr. 2016 Aug; 175: 106-10.e2
12.Pavord Sue, Myers Bethan, Robinson Susan, Allard Shubha, Strong Jane, Oppenheimer Christina. UK guidelines on the management of iron deficiency in pregnancy. British Journal of Hematology. March 2012; 156(5):588-600
13.Olus Api, Christian Breyman, Mustafa Cetiner, Cansun Demir, Tevfik Ecder. Diagnosis and treatment of iron deficiency anemia during pregnancy and the postpartum period: Iron deficiency anemia working group consensus report. Turk J Obstet Gynecol. 2015 Sep; 12(3):173-81
14.ACOG - American College of Obstetricians and Gynecologists practice Bulletin no. 95: anemia in pregnancy. Obstetrics and Gynecology. 2008; 112:201-7
15.Breymann C, Bian XM, Blanco-Capito LR, Chong C, Mahmud G, Rehman R. Expert recommendations for the diagnosis and treatment of iron-deficiency anemia during pregnancy and the postpartum period in the Asia-Pacific region. Journal of Perinatal Medicine. 2011; 39:113-21
16.WHO Guideline: Daily Iron and Folic Acid Supplementation in Pregnant Women. World Health Organization, Geneva, Switzerland. 2012. (http://www.who.int/nutrition/publications/micronutrients/guidelines/daily_iron_supp_womenandgirls.pdf, accesat [30 noiembrie 2018])
17.Moretti D, Goede JS, Zeder C et al. Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young women. Blood, 2015; 126:1981-89
18.WHO. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Vitamin and Mineral Nutrition Information System. Geneva, World Health Organization, 2011 (WHO/NMH/NHD/MNM/11.1) (http://www.who.int/vmnis/indicators/haemoglobin.pdf, accesat [30 noiembrie 2018])
19.Munoz M, Pena-Rosas JP, Robinson S, Miman N, Holzgneve W, Breymann C, Goffinet F, Nizzard J, Christory F, Samama CM, et al. Patient blood management in obstetrics: Management of anaemia and hematinic deficiencies in pregnancy and in the post-partum period: NATA consensus statement. Transfus. Med. 2018; 28:22-39
20.Maureen M. Achebe and Anat Gafter-Gvili. How I treat anemia in pregnancy: iron, cobalamin, and folate. Blood 2017; 129:940-9
21.Auerbach Michael. Commentary: Iron deficiency of pregnancy - a new approach involving intravenous iron. Reprod Health. 2018; 15(1):96. doi: [10.1186/s12978-018-0536-1]
22.Mishra V, Gandhi K, Roy P, Hokabaj S, Shah KN. Role of Intravenous Ferric Carboxy-maltose in Pregnant Women with Iron Deficiency Anaemia. J Nepal Health Res Counc. 2017 Sep 8;15(2):96-99
23.Abdelazim IA, Nusair B, Svetlana S, Zhurabekova. Treatment of iron deficiency and iron deficiency anemia with intravenous ferric carboxymaltose in pregnancy. Arch Gynecol Obstet. 2018 Oct 22. doi: 10.1007/s00404-018-4943-x
24.EMA (2013) New Recommendations to Manage Risk of Allergic Reactions with Intravenous Iron-Containing Medicines. European Medicines Agency, London, UK. https://www.ema.europa.eu/documents/press-release/new-recommendations-manage-risk-allergic-reactions-intravenous-iron-containing-medicines_en.pdf, accesat [30 noiembrie 2018])
25.Milman N. Iron Deficiency and Anaemia in Pregnant Women in Malaysia - Still a Significant and Challenging Health Problem. 2015; J Preg Child Health. 2:168. doi: 10.4172/2376-127X.1000168
26.Rampton D, Folkersen J, Fishbane S, et al. Hypersensitivity reactions to intravenous iron: guidance for risk minimization and management. Haematologica. 2014; 99:1671-6
27.Auerbach M, Adamson J, Bircher A, et al. On the safety of intravenous iron, evidence trumps conjecture. Haematologica. 2015; 100: e214-e215
28.Sunita Dubey, Vanita Suri, Neelam Aggarawal, Reena Das. Is it safe to use intravenous iron sucrose during pregnancy? A randomized controlled trial. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2013; 2(4):544-9
29.Dipti Agrawal, Sunita Fotedar, Shamoli Kundu, Monika Mourya. Iron Sucrose infusion in Pregnancy: a comparative study. Annals of Applied Bio-sciences. 2014;1:A40-44
30.Shruti B Bhavi, Purushottam B Jaju. Intravenous iron sucrose v/s oral ferrous fumarate for treatment of anemia in pregnancy. A randomized controlled trial. BMC Pregnancy Childbirth. 2017; 17:137. doi: [10.1186/s12884-017-1313-9]
31.Amreen Naqash, Rifat Ara, Ghulam N. Bader. Effectiveness and safety of ferric carboxymaltose compared to iron sucrose in women with iron deficiency anemia: phase IV clinical trials. BMC Womens Health. 2018; 18: 6. doi: [10.1186/s12905-017-0506-8]
32.Alaa Qassim, Ben W Mol, Rosalie M Grivell, Luke E Grzeskowiak. Safety and efficacy of intravenous iron polymaltose, iron sucrose and ferric carboxymaltose in pregnancy: A systematic review. Aust N Z J Obstet Gynaecol 2018; 58: 22-39
33.ORDIN nr. 910/18 XI 2002 privind criteriile de ierarhizare a secţiilor de spital de specialitate obstetrică, ginecologie şi neonatologie cu completările şi modificările OMS 272/2009